Toxicology data bases consulted

The first stage consists of identifying the chemical substance by using the “international passport”, i.e. the CAS registry number.
Five “identification” data bases have been selected; they were chosen because of the number of substances recorded and for the synonym and translation options:

• Reptox (Commission de la Santé et de la Sécurité du Travail - Occupational Health & Safety Board, Quebec, Canada)

• Chemindex (Commission de la Santé et de la Sécurité du Travail – Occupational Health & Safety Board, Quebec, Canada)

• NIOSH (Centers for Disease Control and Prevention, USA)

• NIOSH & Institut Scientifique de la Santé Publique - Scientific Institute of Public Health, Belgium)

• ChemIndustry.com (USA)

Furêtox has data on more than 200 000 names of compounds.

A further twelve data bases referencing “chronic HHTVs” were selected because they are run by recognised English-speaking and/or French-speaking scientific organisations and offer free Internet access.

The list does not claim to be exhaustive, but has information which can provide answers, or partial answers, to environmental health questions that professionals often have to deal with.
Data bases providing guidance values for environmental compartments only were not selected. The RAIS database compiling HHTVs established by other bodies was initially selected but could not be included in Furetox because of its structural design.

 View data bases selected for chronic HHTVs :

 Four databases, chosen according to the same selection criteria, have carcinogenicity classifications.

 List of databases with carcinogenicity classifications

• Centre International de Recherche sur le Cancer (CIRC)

• US Environmental Protection Agency

• Health Canada

• European Union (ECB: European Chemical Bureau)

   

   

  Toxicology data bases consulted - synopsis

   

  Organisation	Data Base	Acronym
  Agency for Toxic Substances and Disease Registry (ATSDR)	Minimal risk levels, Toxicological profile Interaction profile	MRL
  Department of Energy (DOE), Office of Environment Management, Oak Ridge Operations (Oro) Office	Risk Assessment Information System / Risk Assessment Toxicity Values	RAIS / RATV
  Health Canada	Health-based guidance values for priority substances
  Institut National de l’Environnement et des Risques Industriels (Ineris - france	Toxicology & Environmental Data Sheets
  Institut National de Recherche Agronomique (Inra-France)	Agritox
  Office of Environmental Health Hazard Assessment of the Californian Environmental Protection Agency (OEHHA – Cal EPA)	Reference Exposure for Airborn Toxicants Water Public Heath Goals Toxicity Criteria Database	Chronic RELs, Acute RELs PHG
  RijksInstituut voor Volksgesondheid en Milieu (RIVM)	Re-evaluationof human toxicological maximum permissible risk levels
  United-States - Environmental Protection Agency (US-EPA)	Integrated Risk Information System Fact sheets on new active ingredients for conventional chemicals	IRIS
  World Health Organisation (WHO)	Guidelines for Drinking Water Quality 3rd edition – 2004 Air Quality Guidelines for Europe – 2000	GDWQ AQGD
  World Health Organisation (WHO) Food & Agriculture Organization (FAO)	Joint Expert Committee on Food and Additives Joint FAO/WHO Meeting on Pesticide Residues	JECFA JMPR
  World Health Organisation (WHO) International Labour Organisation (ILO), United Nations Environment Programme (UNEP)	Concise International Chemical Assessment Documents - International Program on Chemical Safety (IPCS)	CICAD